HOW DOES SAW PALMETTO WORK: PREVENTING THE BINDING OF DHT TO ANDROGEN RECEPTORS IN PROSTATE CEILS
After DHT is converted from testosterone, it has the ability to go to the prostate cell, attach to the DNA, and influence it to make specific enzymes and proteins. This could lead to prostatic growth. One of the presumed ways SP could work is by attaching itself to the DHT receptor on the prostate cell membrane, or somewhere inside the prostate cell thus preventing the action of DHT. This could be compared to trying to open the door of a house with the key but a neighborhood teenager has played a trick. He has filled the hole with a piece of gum. The key is unable to enter the keyhole, and the door won't open.
In a study conducted at the Department of Obstetrics and Gynecology at King Khalid University Hospital in Riyadh, Saudi Arabia, Permixon (the lipid extract of SP) was dissolved in 9 different tissues of human tissue specimens. These included uterine, vaginal skin, abdominal wall skin, and skin from circumcised babies. In all of the specimens, SP was able to block DHT receptors by about 40 percent. The researchers stated, "Since hirsutism [excessive hair growth on the face and body, especially in women] and virilism [masculinization] are among gynecological problems caused either by excessive androgen stimulation or excess end organ response, we suggest that Permixon could be a useful treatment in such conditions and recommend further investigations of the possible therapeutic values of the drug in gynecological practice."
Whether SP will have a role to play in acne, hair loss, or other conditions associated with excessive androgen stimulation, has not been fully determined at this time.
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